Upper Hampton Lake is located within the Columbia National Wildlife Refuge (CNWR) south of Potholes Reservoir. WDFW fishing regulations and licenses apply to all lakes within this federal refuge. Vehicle or walk-in access to these lakes is managed by the USFWS. WDFW recommends that anglers review access and other regulations on the CNWR website (http://www.fws.gov/columbia/). Anglers must make a short hike from the Lower Hampton Lake access area to fish Upper Hampton Lake.
Fishing at Upper Hampton Lake has been poor-fair for the past five to six years. Nice size trout up to and exceeding 20 inches inhabit the lake, but total trout abundance is low due to the presence of nuisance fish species. WDFW is planning to rehabilitate Upper Hampton Lake in 2013 to restore the trout fishery.